Results
| PMID | 17545054 |
| Gene Name | HIF1A |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 108 |
| Population details | 108 (20 normal endometrium, 20 ectopic endometrium, 68 eutopic endometrium specimens from 68 endometriosis patients) |
| Sex | Female |
| Associated genes | HIF-1alpha |
| Other associated phenotypes |
Endometriosis |
|
Nan Fang Yi Ke Da Xue Xue Bao. 2007 Apr;27(4):538-40. Ren, Xu| He, Yuan-li| Pan, Shi-lei| Peng, Dong-xian Department of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. renxu@fimmu.com OBJECTIVE: To detect the expression of hypoxia-inducible factor-1alpha(HIF-1alpha) in endometriosis and explore the possible role of HIF-1alpha in the pathogenesis of endometriosis. METHODS: Immunohistochemistry was performed to examine the expression of HIF-1alpha in 20 normal endometrium, 20 ectopic endometrium and 68 eutopic endometrium specimens from 68 endometriosis patients, and the results were analyzed statistically. RESULTS: The expression of HIF-1alpha was significantly increased in ectopic endometrium than in normal endometrium (P<0.01), and the expression did not undergo changes with the normal menstrual cycle in the three types of endometrium. CONCLUSION: HIF-1alpha expression increases in ectopic endometrium, suggesting that HIF-1alpha plays an important role in the pathogenesis of endometriosis. Mesh Terms: Adult| Endometriosis/*genetics| Endometrium/*metabolism| Female| Humans| Hypoxia-Inducible Factor 1, alpha Subunit/*genetics/metabolism| Menstrual Cycle/metabolism|DA 2010/05/12 06:00 |
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